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. 1995 Mar;39(3):769-70.
doi: 10.1128/AAC.39.3.769.

Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis

N Honoré  1 , G Marchal, S T Cole
Affiliations

Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis

N Honoré et al. Antimicrob Agents Chemother. 1995 Mar.

Abstract

Molecular characterization of a streptomycin-dependent mutant of Mycobacterium tuberculosis revealed the presence of a novel mutation in the rrs gene encoding 16S rRNA. Insertion of an additional cytosine in the 530 loop of 16S rRNA, a region known to be involved in streptomycin susceptibility and resistance, was associated with streptomycin dependence.

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