Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995;256(2):85-8.
doi: 10.1007/BF00634713.

The relation between depth of trophoblastic invasion and beta-HCG levels in tubal pregnancies

Affiliations

The relation between depth of trophoblastic invasion and beta-HCG levels in tubal pregnancies

M Klein et al. Arch Gynecol Obstet. 1995.

Abstract

beta-HCG (human chorionic gonadotropin) values of over 2500 I.U./l are associated with higher failure rates for therapy with prostaglandin F2 alpha in tubal pregnancies. The purpose of our study was to ascertain if the 2500 I.U./l limit correlates with histopathology. We therefore compared the pre-operative beta-HCG-values and intraluminal and extraluminal trophoblast growth in tubal pregnancy. Purely intraluminal trophoblast was significantly more frequent in patients of group I (beta-HCG < 2500 I.U./l), while group II patients (beta-HCG > 2500 I.U./l) almost exclusively had extraluminal growth (P = 0.0045). Since the efficacy of prostaglandin F2 alpha therapy depends on intact tubal musculature the correlation of the beta-HCG threshold level with histopathologic findings may explain the high failure rate in patients with beta-HCG values above 2500 I.U./l.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Br J Obstet Gynaecol. 1989 Jun;96(6):725-8 - PubMed
    1. Geburtshilfe Frauenheilkd. 1989 Sep;49(9):808-12 - PubMed
    1. Wien Klin Wochenschr. 1990 Aug 3;102(15):454-9 - PubMed
    1. Lancet. 1989 Oct 14;2(8668):922-3 - PubMed
    1. Lancet. 1988 May 14;1(8594):1104-5 - PubMed

LinkOut - more resources