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. 1995;8(4):261-5.
doi: 10.3109/14756369509020133.

2'-Fluoropolynucleotide-directed reverse transcriptase reactions. Effect of homologous polynucleotides

M B Juca  1 , H Aoyama
Affiliations

2'-Fluoropolynucleotide-directed reverse transcriptase reactions. Effect of homologous polynucleotides

M B Juca et al. J Enzyme Inhib. 1995.

Abstract

Several homologous polynucleotides have been tested as inhibitors on the reactions catalyzed by avian myeloblastosis virus (AMV) reverse transcriptase, in the presence of polyribonucleotides and 2'-fluorinated polynucleotides as templates. Polynucleotides differentially inhibited the reactions catalyzed by reverse transcriptase in the presence of these synthetic templates. Polyriboadenylic acid (poly(rA), poly(2'-O-methyladenylic acid) (poly(Am)), poly(2'-fluoro-2'-deoxyadenylic acid) (poly(dAfl), polyinosinic acid (poly(rI)) and polyuridylic acid poly(rU)) inhibited the polyribonucleotide-, but not the 2'-fluorinated polynucleotide-directed reverse transcriptase activity.

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