doi: 10.3109/14756369509020133.
2'-Fluoropolynucleotide-directed reverse transcriptase reactions. Effect of homologous polynucleotides
Affiliations
- PMID: 7542323
- DOI: 10.3109/14756369509020133
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2'-Fluoropolynucleotide-directed reverse transcriptase reactions. Effect of homologous polynucleotides
J Enzyme Inhib.
1995.
Abstract
Several homologous polynucleotides have been tested as inhibitors on the reactions catalyzed by avian myeloblastosis virus (AMV) reverse transcriptase, in the presence of polyribonucleotides and 2'-fluorinated polynucleotides as templates. Polynucleotides differentially inhibited the reactions catalyzed by reverse transcriptase in the presence of these synthetic templates. Polyriboadenylic acid (poly(rA), poly(2'-O-methyladenylic acid) (poly(Am)), poly(2'-fluoro-2'-deoxyadenylic acid) (poly(dAfl), polyinosinic acid (poly(rI)) and polyuridylic acid poly(rU)) inhibited the polyribonucleotide-, but not the 2'-fluorinated polynucleotide-directed reverse transcriptase activity.
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