CD1-restricted T cell recognition of microbial lipoglycan antigens
- PMID: 7542404
- DOI: 10.1126/science.7542404
CD1-restricted T cell recognition of microbial lipoglycan antigens
Abstract
It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with alpha(1-->2) linkages and a phosphotidylinositol unit. T cells activated by LAM produced interferon gamma and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells.
Comment in
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CD1: presenting unusual antigens to unusual T lymphocytes.Science. 1995 Jul 14;269(5221):185-6. doi: 10.1126/science.7542402. Science. 1995. PMID: 7542402 Review. No abstract available.
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