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. 1995 Jul 28;269(5223):496-512.
doi: 10.1126/science.7542800.

Whole-genome random sequencing and assembly of Haemophilus influenzae Rd

R D Fleischmann  1 , M D Adams, O White, R A Clayton, E F Kirkness, A R Kerlavage, C J Bult, J F Tomb, B A Dougherty, J M Merrick, et al.
Affiliations

Whole-genome random sequencing and assembly of Haemophilus influenzae Rd

R D Fleischmann et al. Science. .

Abstract

An approach for genome analysis based on sequencing and assembly of unselected pieces of DNA from the whole chromosome has been applied to obtain the complete nucleotide sequence (1,830,137 base pairs) of the genome from the bacterium Haemophilus influenzae Rd. This approach eliminates the need for initial mapping efforts and is therefore applicable to the vast array of microbial species for which genome maps are unavailable. The H. influenzae Rd genome sequence (Genome Sequence DataBase accession number L42023) represents the only complete genome sequence from a free-living organism.

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Comment in

  • Pioneering work.
    Fiers W. Fiers W. Science. 1995 Sep 29;269(5232):1805. doi: 10.1126/science.269.5232.1805-b. Science. 1995. PMID: 7569908 No abstract available.
  • Bacterial genome sequence bagged.
    Nowak R. Nowak R. Science. 1995 Jul 28;269(5223):468-70. doi: 10.1126/science.7624767. Science. 1995. PMID: 7624767 No abstract available.
  • More Haemophilus and Mycoplasma genes.
    Brosius J. Brosius J. Science. 1996 Mar 1;271(5253):1302; author reply 1303-4. Science. 1996. PMID: 8638117 No abstract available.
  • More Haemophilus and Mycoplasma genes.
    Robison K, Gilbert W, Church GM. Robison K, et al. Science. 1996 Mar 1;271(5253):1302-3; author reply 1303-4. Science. 1996. PMID: 8638118 No abstract available.

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