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. 1995 Jul 28;269(5223):535-7.
doi: 10.1126/science.7542801.

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

A Tarakhovsky  1 , S B Kanner, J Hombach, J A Ledbetter, W Müller, N Killeen, K Rajewsky
Affiliations

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

A Tarakhovsky et al. Science. .

Abstract

CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered thymocytes hyperresponsive to stimulation through the T cell antigen receptor (TCR) in vitro. Selection of T cells expressing three distinct transgenic TCRs was also abnormal in CD5-deficient mice. These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction.

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