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. 1995 Aug 4;269(5224):688-90.
doi: 10.1126/science.7542803.

Molecular identification of an IgE-dependent histamine-releasing factor

S M MacDonald  1 , T Rafnar, J Langdon, L M Lichtenstein
Affiliations

Molecular identification of an IgE-dependent histamine-releasing factor

S M MacDonald et al. Science. .

Abstract

An immunoglobulin E (IgE)-dependent histamine-releasing factor (HRF) produced by lymphocytes of atopic children and present in biological fluids of allergic patients has been identified and purified. Amino-terminal sequencing revealed extensive homology to a mouse protein, p21, and its human homolog, p23. Both recombinant proteins caused histamine release from the human basophils of a subpopulation of donors, and this release was dependent on IgE. Polyclonal antibodies recognized and removed the biological activity of recombinant and native HRF. HRF identifies a heterogeneity of IgE and is believed to play a prominent role in chronic allergic disease processes.

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