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. 1995;36(4):279-82.
doi: 10.1007/BF00689043.

Taxol encapsulation in poly(epsilon-caprolactone) microspheres

S K Dordunoo  1 , J K Jackson, L A Arsenault, A M Oktaba, W L Hunter, H M Burt
Affiliations

Taxol encapsulation in poly(epsilon-caprolactone) microspheres

S K Dordunoo et al. Cancer Chemother Pharmacol. 1995.

Abstract

Poly(epsilon-caprolactone) (PCL) microspheres containing taxol were prepared by the solvent evaporation method and tested for angiogenesis inhibition using the chick chorioallantoic membrane (CAM) model. Very high encapsulation efficiencies (95%) for taxol in PCL microspheres were obtained. In vitro release studies showed about 25% of the loaded drug was released in 6 weeks from microspheres containing 5% taxol. Studies with the CAM showed that taxol released from the microspheres induced vascular regression and inhibited angiogenesis.

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