Review
doi: 10.1016/s0968-0004(00)89022-2.
Rho as a regulator of the cytoskeleton
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- PMID: 7543224
- DOI: 10.1016/s0968-0004(00)89022-2
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Review
Rho as a regulator of the cytoskeleton
Trends Biochem Sci.
1995 Jun.
Abstract
Many cell functions, including maintenance of morphology, aggregation, motility, membrane ruffling, smooth-muscle contraction, cytokinesis in mammals and bud formation in yeast, are regulated through the dynamic reorganization of actin filaments. Although it has long been known that Ca2+ is a key regulator of the cytoskeleton, evidence is now accumulating that Rho, a Ras-related small GTP-binding protein, is another important regulator of these actin-dependent cell functions.
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