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Comparative Study
. 1995 Sep;69(9):5821-3.
doi: 10.1128/JVI.69.9.5821-5823.1995.

Cyclophilin binding to the human immunodeficiency virus type 1 Gag polyprotein is mimicked by an anti-cyclosporine antibody

E K Franke  1 , B X Chen, I Tatsis, A Diamanduros, B F Erlanger, J Luban
Affiliations
Comparative Study

Cyclophilin binding to the human immunodeficiency virus type 1 Gag polyprotein is mimicked by an anti-cyclosporine antibody

E K Franke et al. J Virol. 1995 Sep.

Abstract

Human immunodeficiency virus type 1 is unique among retroviruses in that infectivity requires specific incorporation into virions of the cellular protein cyclophilin A through interactions with the Gag polyprotein. Here we show that monoclonal antibody B11 1.4, which recognizes a cyclophilin-binding epitope on cyclosporine, detects denatured or native human immunodeficiency virus type 1 capsid. B11 1.4 does not recognize the capsids of other retroviruses, and binding is inhibited by cyclosporine or by cyclophilin A.

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