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. 1995;30(4):254-7.

[Effect of tremulacin on actions of SRS-A and histamine]

[Article in Chinese]
D X Yang  1 , K Q He, G F Cheng
Affiliations
  • PMID: 7544944

[Effect of tremulacin on actions of SRS-A and histamine]

[Article in Chinese]
D X Yang et al. Yao Xue Xue Bao. 1995.

Abstract

The effect of tremulacin (TRC) extracted from Mao Bai Yang (Folia Populus tomentosa Carr) on actions of SRS-A and histamine were investigated by using isolated guinea pig ileum and spectrofluorometric assay. TRC was found to inhibit the contraction of isolated guinea pig ileum induced by histamine and SRS-A, in a dose-dependent manner with IC50 of 1.78 x 10(-4) mol.L-1 and 2.51 x 10(-4) mol.L-1, respectively. TRC at the dose of 10(-4) mol.L-1 inhibited SRS-A release from sensitized isolated guinea pig lung. While at the dose of 10(-5) mol.L-1 inhibited histamine release from the peritoneal mast cells in sensitized rats. These results indicate that inhibition of the release of histamine and SRS-A may play an important role in the mechanism of antiinflammatory actions of TRC.

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