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Review
. 1995 Apr;7(2):196-205.
doi: 10.1016/0952-7915(95)80004-2.

Intrathymic and extrathymic clonal deletion of T cells

J Sprent  1 , S R Webb
Affiliations
Review

Intrathymic and extrathymic clonal deletion of T cells

J Sprent et al. Curr Opin Immunol. 1995 Apr.

Abstract

Clonal elimination accounts for self-tolerance induction in the thymus and also affects mature T cells responding to exogenous antigens in the periphery. Recent evidence on the microenvironments, cell-cell interactions and signalling requirements for clonal deletion of immature and mature T cells is discussed.

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