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Comparative Study
. 1995 Sep;40(1):129-34.
doi: 10.1016/0031-9422(95)00212-p.

Cytotoxic biflavonoids from Selaginella willdenowii

G L Silva  1 , H Chai, M P Gupta, N R Farnsworth, G A Cordell, J M Pezzuto, C W Beecher, A D Kinghorn
Affiliations
Comparative Study

Cytotoxic biflavonoids from Selaginella willdenowii

G L Silva et al. Phytochemistry. 1995 Sep.

Abstract

Bioactivity-guided fractionation of the leaves of Selaginella willdenowii afforded three known biflavones, 4',7"-di-O-methylamentoflavone, isocryptomerin and 7"-O-methylrobustaflavone, that were significantly cytotoxic against a panel of human cancer cell lines. Non-cytotoxic isolates were also obtained, namely, amentoflavone, bilobetin, robustaflavone and 2",3"-dihydroisocryptomerin, a new dihydrobiflavone. The structure for the new biflavonoid was unambiguously assigned by a combination of spectroscopic methods.

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