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Clinical Trial
. 1995 Jun;161(6):431-3.

Timing of antibiotic treatment in non-perforated gangrenous appendicitis

P Almqvist  1 , L Leandoer, A Törnqvist
Affiliations
  • PMID: 7548380
Clinical Trial

Timing of antibiotic treatment in non-perforated gangrenous appendicitis

P Almqvist et al. Eur J Surg. 1995 Jun.

Abstract

Objective: To assess whether antibiotic treatment with cefuroxime and tinidazole started during the operation was as effective as treatment started before operation in patients with gangrenous non-perforated appendicitis.

Design: Prospective randomised study.

Setting: University hospital, Sweden.

Subjects: 114 patients with gangrenous, non-perforated appendicitis who had had antibiotics started before operation and 120 whose treatment was started during operation out of a total of 575 who presented with a presumptive diagnosis of appendicitis.

Main outcome measures: Morbidity and mortality.

Results: There were no deaths, and the rates of infective complications were 1/114 (0.9%) and 3/120 (3%), respectively. The median hospital stay was four days in both groups.

Conclusion: Antibiotic treatment started during the operation is not significantly worse at preventing infective complications in non-perforated, gangrenous appendicitis than treatment started before the operation.

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