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. 1994 Nov;27(11):2635-8.

Inhibition of bovine brain acetylcholinesterase by aluminum

M S Moraes  1 , S R Leite
Affiliations
  • PMID: 7549986

Inhibition of bovine brain acetylcholinesterase by aluminum

M S Moraes et al. Braz J Med Biol Res. 1994 Nov.

Abstract

We report the in vitro inhibitory effect of very low concentrations of aluminum salts (IC50 = 4.1 x 10(-12 M) on bovine brain acetylcholinesterase (AChE). The enzymatic assays were performed using acetylcholine bromide in a buffered pH 7.4 solution at 37 degrees C. The relevant enzyme interacting species is the Al3+ ion, whose concentrations were fixed at pM levels by a citrate metal ion buffer system. The IC50 demonstrates that Al3+ is a potent inhibitor of AChE.

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