Zinc distribution and metallothionein in the liver and kidney of mice treated with cadmium

Abstract

Cadmium in the liver and kidney increased with the dosage of this injection. There was a parallel relation between the increase of cadmium in the whole liver and that in the metallothionein. In the liver and kidney, zinc highly increased in the low dose group than in the high dose group. In the 5.0 mg/kg group, zinc in the liver was not different from that of the control group, and about 30% of zinc in the 30,000 g supernatant existed in the metallothionein. By the DEAE-cellulose chromatography of metallothionein, two forms of metallothionein were obtained.