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Review
. 1995 Jun 1;5(6):615-7.
doi: 10.1016/s0960-9822(95)00124-2.

Integrin-ligand binding. Do integrins use a 'MIDAS touch' to grasp an Asp?

J M Bergelson  1 , M E Hemler
Affiliations
Free article
Review

Integrin-ligand binding. Do integrins use a 'MIDAS touch' to grasp an Asp?

J M Bergelson et al. Curr Biol. .
Free article

Abstract

Integrins use divalent cations, held within a novel 'MIDAS' motif, for ligand binding. It is proposed that a missing coordination site for the cation is provided by a critical acidic residue in the ligand.

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