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. 1995 Sep;2(9):715-8.
doi: 10.1038/nsb0995-715.

Scratching the surface with the PH domain

K M Ferguson, M A Lemmon, P B Sigler, J Schlessinger

Scratching the surface with the PH domain

K M Ferguson et al. Nat Struct Biol. 1995 Sep.

Abstract

Pleckstrin homology (PH) domains bind to membrane surfaces, and inositol phospholipids appear to form part of the binding sites. Recent structural studies provide a model for PH domain anchoring to inositol phospholipids that will open new avenues for functional investigation.

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