Crystal structures of B-form DNA-RNA chimers complexed with distamycin
- PMID: 7552741
- DOI: 10.1038/nsb0995-733
Crystal structures of B-form DNA-RNA chimers complexed with distamycin
Abstract
Two DNA-RNA chimers, complexed with DNA minor groove binding drugs, have been observed to adopt the B-form conformation for the first time. Thus, the RNA duplex may assume the B-DNA conformation when interacting with drugs, peptides or proteins.
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