Review
doi: 10.1016/s0090-1229(95)90126-4.
Immunodeficiency in IL-2-knockout mice
Affiliations
- PMID: 7554463
- DOI: 10.1016/s0090-1229(95)90126-4
Item in Clipboard
Review
Immunodeficiency in IL-2-knockout mice
Clin Immunol Immunopathol.
1995 Sep.
Abstract
Interleukin-2-deficient mice (IL-2-/-) generated by targeted mutagenesis proved to be an excellent system to study the function of this lymphokine in the context of whole immune system. In addition, they provide an animal model of a primary immunodeficiency caused by a single-gene defect. Our results indicate that the essential degect in IL-2-/- mice is the lack of a negative regulatory function, which leads to breakdown of self tolerance. The development of autoimmune diseases in IL-2-deficient mice stresses the link between autoimmunity and primary immunodeficiencies.
Similar articles
-
Interleukin-2-knockout mice: a new model to study autoimmunity and self-tolerance.Sb Lek. 1996;97(1):25-8. Sb Lek. 1996. PMID: 8711415
-
Murine models of immunodeficiency and autoimmune disease.Curr Protoc Immunol. 2001 May;Appendix 1:Appendix 1E. doi: 10.1002/0471142735.ima01es17. Curr Protoc Immunol. 2001. PMID: 18432641
-
Immune deficiency disorders with autoimmunity and abnormalities in immune regulation-monogenic autoimmune diseases.Clin Rev Allergy Immunol. 2008 Apr;34(2):141-5. doi: 10.1007/s12016-007-8038-x. Clin Rev Allergy Immunol. 2008. PMID: 18330725 Review.
-
Autoimmunity and primary immunodeficiency: two sides of the same coin?Nat Rev Rheumatol. 2017 Dec 19;14(1):7-18. doi: 10.1038/nrrheum.2017.198. Nat Rev Rheumatol. 2017. PMID: 29255211 Review.
-
Monogenic polyautoimmunity in primary immunodeficiency diseases.Autoimmun Rev. 2018 Oct;17(10):1028-1039. doi: 10.1016/j.autrev.2018.05.001. Epub 2018 Aug 11. Autoimmun Rev. 2018. PMID: 30107266 Review.
Cited by
-
Effects of Brain-Derived IL-2 Deficiency and the Development of Autoimmunity on Spatial Learning and Fear Conditioning.J Neurol Disord. 2015;3(1):196. doi: 10.4172/2329-6895.1000196. J Neurol Disord. 2015. PMID: 25961067 Free PMC article.
-
Autoimmunity, immunodeficiency and mucosal infections: chronic intestinal inflammation as a sensitive indicator of immunoregulatory defects in response to normal luminal microflora.Folia Microbiol (Praha). 1998;43(5):545-50. doi: 10.1007/BF02820817. Folia Microbiol (Praha). 1998. PMID: 9821323 Review.
-
Loss of cholinergic phenotype in septohippocampal projection neurons: relation to brain versus peripheral IL-2 deficiency.Neurosci Lett. 2013 Feb 28;539:60-4. doi: 10.1016/j.neulet.2013.01.054. Epub 2013 Feb 13. Neurosci Lett. 2013. PMID: 23416322 Free PMC article.
-
The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role.Front Cell Infect Microbiol. 2021 Nov 17;11:758273. doi: 10.3389/fcimb.2021.758273. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34869064 Free PMC article.
-
Phenotypic and Functional Changes of Peripheral Ly6C+ T Regulatory Cells Driven by Conventional Effector T Cells.Front Immunol. 2018 Mar 16;9:437. doi: 10.3389/fimmu.2018.00437. eCollection 2018. Front Immunol. 2018. PMID: 29616017 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Molecular Biology Databases