Review
doi: 10.1016/s0090-1229(95)90252-x.
CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)
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- PMID: 7554470
- DOI: 10.1016/s0090-1229(95)90252-x
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Review
CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)
Clin Immunol Immunopathol.
1995 Sep.
Abstract
Interactions between the B cell surface antigen CD40 and its ligand (CD40L) expressed on activated T cells play a critical role in isotype switching. This is illustrated by failure of isotype switching in patients with X-linked hyperIgM syndrome in whom the CD40L gene is mutated and by failure of isotype switching of CD40-deficient mice in response to T-cell-dependent antigens. We review these findings and discuss the signaling mechanisms of CD40 and the developmental control and transcriptional regulation of CD40L expression.
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