doi: 10.1073/pnas.75.1.441.
Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes
- PMID: 75547
- PMCID: PMC411265
- DOI: 10.1073/pnas.75.1.441
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Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes
Proc Natl Acad Sci U S A.
1978 Jan.
Abstract
During each transplantation passage of a line of mouse myeloma tumor MOPC-315 through syngeneic (BALB/c) hosts, the tumor cells lose reactivity with cytotoxic thymus-derived lymphocytes directed against products of the BALB/c major histocompatibility complex (H-2d) and regain reactivity on transfer to fresh hosts. In contrast to this cyclical change, the tumor cells remain uniformly reactive with anti-H-2d alloantisera throughout the transplantation cycle.
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