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. 1978 Jan;75(1):441-5.
doi: 10.1073/pnas.75.1.441.

Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes

J H Russell, A H Hale, L C Ginns, H N Eisen

Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes

J H Russell et al. Proc Natl Acad Sci U S A. 1978 Jan.

Abstract

During each transplantation passage of a line of mouse myeloma tumor MOPC-315 through syngeneic (BALB/c) hosts, the tumor cells lose reactivity with cytotoxic thymus-derived lymphocytes directed against products of the BALB/c major histocompatibility complex (H-2d) and regain reactivity on transfer to fresh hosts. In contrast to this cyclical change, the tumor cells remain uniformly reactive with anti-H-2d alloantisera throughout the transplantation cycle.

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References

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