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Clinical Trial
. 1995 Jun;38(3):213-9.
doi: 10.1016/0376-8716(95)01101-4.

Double-blind comparison of carbamazepine and placebo for treatment of cocaine dependence

I D Montoya  1 , F R Levin, P J Fudala, D A Gorelick
Affiliations
Clinical Trial

Double-blind comparison of carbamazepine and placebo for treatment of cocaine dependence

I D Montoya et al. Drug Alcohol Depend. 1995 Jun.

Abstract

This study was conducted to determine the effectiveness of carbamazepine (CBZ) for treatment of cocaine dependence. Sixty-two (CBZ = 28, placebo = 34) cocaine-dependent (DSM-III-R criteria) volunteers consented to be treated for eight weeks with standardized outpatient individual counseling twice a week plus double-blind CBZ or inactive placebo. During the 8-week trial, both groups showed increased number of urine samples negative for cocaine, significantly (P < 0.01) decreased self-reported cocaine use (money spent and grams used), and decreased Beck Depression Inventory and Symptom Check List-90-Revised (SCL-90-R) total scores. However, there were no significant differences between CBZ and placebo. This study does not support the effectiveness of CBZ for outpatient treatment of cocaine dependence.

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Figures

Fig. 1
Fig. 1
There were no significant differences between CBZ (■, n = 28) and placebo (○, n = 34) for retention in treatment for cocaine dependence (62 patients completing one week of treatment).
Fig. 2
Fig. 2
Mean (SE) percentage of urines negative for cocaine at week 1 of and discharge from (End Tx) treatment. There were no significant differences between CBZ (■, n = 28) and placebo (□, n = 34).
See this image and copyright information in PMC

Comment in

References

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