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Clinical Trial
. 1995 Jun;38(3):221-7.
doi: 10.1016/0376-8716(95)01102-5.

Carbamazepine treatment for cocaine dependence

J W Cornish  1 , I Maany, P J Fudala, S Neal, S A Poole, P Volpicelli, C P O'Brien
Affiliations
Free article
Clinical Trial

Carbamazepine treatment for cocaine dependence

J W Cornish et al. Drug Alcohol Depend. 1995 Jun.
Free article

Abstract

We report on a double-blind, placebo-controlled study of carbamazepine (CBZ) treatment for cocaine dependence. A previously reported uncontrolled study found CBZ to be a beneficial pharmacotherapy for cocaine dependence. Statistical analyses were performed on data from 82 subjects who were randomized to 10 weeks' treatment with either CBZ, titrated to 4-12 micrograms/ml, (n = 37) or placebo (n = 45). The two treatment groups did not differ for primary outcome measures of retention time in treatment, urine samples positive for cocaine metabolite, subject reported desire for cocaine or for subject reported side-effects. CBZ was not an effective treatment in this study.

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