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Case Reports
. 1995 Jul;154(7):539-41.
doi: 10.1007/BF02074830.

Histiocytic haemophagocytosis in a patient with Kawasaki disease: changes in the hypercytokinaemic state

S Ohga  1 , A Ooshima, J Fukushige, K Ueda
Affiliations
Case Reports

Histiocytic haemophagocytosis in a patient with Kawasaki disease: changes in the hypercytokinaemic state

S Ohga et al. Eur J Pediatr. 1995 Jul.

Abstract

A 32-month-old Japanese boy exhibited haemophagocytic syndrome (HPS) during the recurrent course of Kawasaki disease. Despite repeated gamma-globulin therapy, he developed cytopenia with marked hepatomegaly and evidence of histiocytic haemophagocytosis in the bone marrow. Serum levels of interferon-gamma and tumour necrosis factor, but not of interleukin-1 beta, increased in parallel with his symptoms. No confirmation was obtained of the association of toxic reactions to the used drugs. No coronary lesions remained as sequelae.

Conclusion: Cytopenia in Kawasaki disease could herald HPS, and the hypercytokinaemia involved in the two febrile syndromes might be of distinct nature.

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