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. 1995 Sep 29;51(9-10):941-4.
doi: 10.1007/BF01921744.

The influence of prostacyclin (PGI2) on contractile properties of isolated right ventricle of rat heart

M Pavlović  1 , D Petković, M Cvetković, D J Macut, K Zdjelar, M Nesić, O Bosnić, R Radulović, M Mihajlović
Affiliations

The influence of prostacyclin (PGI2) on contractile properties of isolated right ventricle of rat heart

M Pavlović et al. Experientia. .

Abstract

The mechanism of the positive inotropic effect of prostacyclin (PGI2) (2.6 x 10(-6) mol/l) on the isolated right ventricle of rat heart was studied. Our results show that the positive inotropic effect of prostacyclin is produced indirectly through beta adrenoceptors and slow Ca2+ channels, because blockade of slow Ca2+ channels with verapamil (10(-6) mol/l) and beta adrenoceptors with propranolol (10(-6) mol/l) abolishes this effect. Alpha adrenoceptors do not mediate the action of PGI2.

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