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. 1995 Sep 11;371(3):300-2.
doi: 10.1016/0014-5793(95)00926-z.

Inhibition of degranulation of human polymorphonuclear leukocytes by complement factor D

N Balke  1 , U Holtkamp, W H Hörl, H Tschesche
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Free article

Inhibition of degranulation of human polymorphonuclear leukocytes by complement factor D

N Balke et al. FEBS Lett. .
Free article

Abstract

A degranulation inhibiting protein could be isolated from human plasma ultrafiltrate by a three-step purification method including ion-exchange chromatography, gelfiltration and affinity-chromatography. The protein was identified as complement factor D by means of sequence analysis. Its degranulation inhibiting activity was determined with regard to its effect on the FNLPNTL-induced lactoferrin secretion of human polymorphonuclear leukocytes. Complement factor D caused a dose-dependent decrease of the FNLPNTL-stimulated lactoferrin degranulation down to 34% of stimulated controls.

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