Variation by age group and seasonality at diagnosis of childhood IDDM in Europe. The EURODIAB ACE Study Group
- PMID: 7556985
- DOI: 10.1007/s001250050359
Variation by age group and seasonality at diagnosis of childhood IDDM in Europe. The EURODIAB ACE Study Group
Abstract
Recent data provided by the EURODIAB ACE study group have confirmed wide variation in the incidence of insulin-dependent diabetes mellitus (IDDM) across Europe. The aim of this report is to compare age-specific incidence and seasonality at clinical onset of IDDM between study regions. Using a uniform methodology, the EURODIAB ACE framework ascertained 3,168 newly-diagnosed cases of IDDM in children under the age of 15 years during 1989-1990. Eighteen percent of the cases were age 0-4 years at diagnosis, 34% were age 5-9 years and 48% were age 10-14 years. Poisson regression analysis suggested that there were highly significant statistical differences in incidence between the three age groups and between the 24 regions. Although incidence rates in the 0-4 year and 5-9 year age groups varied from region to region in a similar fashion, the pattern of variation in the older age group was different. Seasonality of diagnosis conformed to a sinusoidal model with a peak occurring in winter, a feature which was consistently observed in both sexes and in all age groups. However, a statistically significant heterogeneity in the seasonal distribution was present among regions, those in Scandinavia showing the smallest relative amplitude. The first insulin injection was given the same day or the day after diagnosis in 93% of the cases for whom data were available.
Similar articles
-
Epidemiology of insulin dependent diabetes before age 20 in Wisconsin, with particular reference to seasonality.Diabetes Res. 1989 Dec;12(4):151-60. Diabetes Res. 1989. PMID: 2637092
-
Comparison of the seasonal pattern in the clinical onset of IDDM in Finland and Sardinia.Diabetes Care. 1998 Jul;21(7):1101-9. doi: 10.2337/diacare.21.7.1101. Diabetes Care. 1998. PMID: 9653603
-
Temporal variation in incidence of IDDM in Canterbury, New Zealand.Diabetes Care. 1992 Jul;15(7):895-9. doi: 10.2337/diacare.15.7.895. Diabetes Care. 1992. PMID: 1516510
-
Incidence of childhood-onset insulin-dependent diabetes mellitus: the EURODIAB ACE Study.Lancet. 1992 Apr 11;339(8798):905-9. doi: 10.1016/0140-6736(92)90938-y. Lancet. 1992. PMID: 1348306
-
A review of the recent epidemiological data on the worldwide incidence of type 1 (insulin-dependent) diabetes mellitus. World Health Organization DIAMOND Project Group.Diabetologia. 1993 Oct;36(10):883-92. doi: 10.1007/BF02374468. Diabetologia. 1993. PMID: 8243865 Review.
Cited by
-
Seasonality in diabetes in Yaounde, Cameroon: a relation with precipitation and temperature.BMC Public Health. 2016 Jun 6;16:470. doi: 10.1186/s12889-016-3090-1. BMC Public Health. 2016. PMID: 27266270 Free PMC article.
-
Seasonality in the manifestation of type 1 diabetes varies according to age at diagnosis in Finnish children.Acta Paediatr. 2022 May;111(5):1061-1069. doi: 10.1111/apa.16282. Epub 2022 Feb 17. Acta Paediatr. 2022. PMID: 35137452 Free PMC article.
-
Current understandings of the pathogenesis of type 1 diabetes: Genetics to environment.World J Diabetes. 2020 Jan 15;11(1):13-25. doi: 10.4239/wjd.v11.i1.13. World J Diabetes. 2020. PMID: 31938470 Free PMC article. Review.
-
Epidemiological issues in diabetic retinopathy.Middle East Afr J Ophthalmol. 2013 Oct-Dec;20(4):293-300. doi: 10.4103/0974-9233.120007. Middle East Afr J Ophthalmol. 2013. PMID: 24339678 Free PMC article. Review.
-
Low mean temperature rather than few sunshine hours are associated with an increased incidence of type 1 diabetes in children.Eur J Epidemiol. 2016 Jan;31(1):61-5. doi: 10.1007/s10654-015-0023-8. Epub 2015 Mar 28. Eur J Epidemiol. 2016. PMID: 25821168
References
Publication types
MeSH terms
LinkOut - more resources
Medical
Miscellaneous