Review
doi: 10.1016/0306-3623(94)00296-y.
Effects of aluminum on neuronal signal transduction: mechanisms underlying disruption of phosphoinositide hydrolysis
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- PMID: 7557263
- DOI: 10.1016/0306-3623(94)00296-y
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Review
Effects of aluminum on neuronal signal transduction: mechanisms underlying disruption of phosphoinositide hydrolysis
Gen Pharmacol.
1995 Sep.
Abstract
1. Aluminum is neurotoxic in humans and animals and alters formation of inositol phosphate (IP) second messengers following in vivo or in vitro exposure. 2. Several components of the IP signalling system including G-proteins, phosphatidylinositol-specific phospholipase C (PI-PLC), protein kinase C (PKC) and Ca2+ homeostasis are susceptible to inhibition/disruption by aluminum compounds. 3. Recent evidence suggests that, despite its effects on other components, competitive inhibition by aluminum of phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis by PI-PLC underlies its effects on agonist-stimulated IP generation.
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