[Antineoplastic chemotherapy in metastatic Wilm's tumor]

Abstract

Wilms tumors may, rarely, also occur in adulthood. A 32-year-old male who, following the removal of a Wilms tumor, developed recurrent disease and metastases to the lungs and liver, was treated with a polychemotherapeutic regimen. Primarily, this was based on the protocol usually applied in children that comprises a combination of actinomycin D, vincristine, and adriamycin. Treatment initially achieved a six-month partial remission. Further treatment became necessary when a recurrence again occurred, and resulted in a "no change" situation that lasted for two months. The subsequent deterioration of the patient prompted monotherapy with vincristine, resulting in a transient clinical improvement. The patient finally died 25 months and two weeks after chemotherapy was first initiated.