Clinical Trial
doi: 10.1007/BF01706205.
Effects of theophylline on renal insufficiency in neonates with respiratory distress syndrome
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- PMID: 7560495
- DOI: 10.1007/BF01706205
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Clinical Trial
Effects of theophylline on renal insufficiency in neonates with respiratory distress syndrome
Intensive Care Med.
1995 Jun.
Abstract
We report here 6 cases of critically ill newborn infants with both RDS and acute renal insufficiency, unresponsive to conventional treatment (furosemide, dopamine). Theophylline, an adenosine antagonist, has been shown to prevent hypoxemia-induced renal insufficiency in rabbits and our patients thus received compassionately a low-dose of theophylline (1 mg . kg-1 i.v.). Urinary water excretion and creatinine clearances increased significantly in 5 out of 6 neonates, thus suggesting a beneficial role of theophylline in neonatal prerenal failure.
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