Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Jul;66(7):397-404.

Tear protein profiles vs. clinical characteristics of untreated and cyclosporine-treated canine KCS

R J Fullard  1 , R M Kaswan, D I Bounous, S G Hirsh
Affiliations
  • PMID: 7560726

Tear protein profiles vs. clinical characteristics of untreated and cyclosporine-treated canine KCS

R J Fullard et al. J Am Optom Assoc. 1995 Jul.

Abstract

Background: Topically administered cyclosporine A (CsA) decreases ocular surface inflammation in canine keratoconjunctivitis sicca (KCS) and exerts lacrimomimetic effects. This study was performed to find correlations between clinical signs and tear protein levels in untreated and CsA-treated canine KCS.

Methods: Clinical profiles were scored in 16 KCS-affected dogs before and 6 weeks after commencing treatment with 0.2% topical CsA emulsion. Tear samples were also collected using polished micropipettes for specific protein assay by high-performance liquid chromatography (HPLC) and enzyme-linked immunosorbent assay (ELISA).

Results: Tear levels of serum proteins correlated with conjunctival clinical signs. Levels of lacrimal gland proteins in tears correlated most often with corneal clinical signs.

Conclusions: The inflammatory features of KCS appear to link conjunctival signs to serum proteins in tears, while corneal signs are linked to lacrimal gland proteins.

PubMed Disclaimer

Publication types

LinkOut - more resources