doi: 10.1021/np50121a007.
Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica
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- PMID: 7561896
- DOI: 10.1021/np50121a007
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Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica
J Nat Prod.
1995 Jul.
Abstract
Three new quassinoid glucosides, bruceosides D [1], E [2], and F [3], were isolated from Brucea javanica, and their structures were elucidated by spectral evidence and chemical transformation to known compounds. Compounds 1-3 show selective cytotoxicity in the leukemia and non-small cell lung, colon, CNS, melanoma, and ovarian cancer cell lines with log GI50 values in the range of -4.14 to -5.72.
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