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. 1995 Jul;58(7):1032-8.
doi: 10.1021/np50121a007.

Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica

S Ohnishi  1 , N Fukamiya, M Okano, K Tagahara, K H Lee
Affiliations

Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica

S Ohnishi et al. J Nat Prod. 1995 Jul.

Abstract

Three new quassinoid glucosides, bruceosides D [1], E [2], and F [3], were isolated from Brucea javanica, and their structures were elucidated by spectral evidence and chemical transformation to known compounds. Compounds 1-3 show selective cytotoxicity in the leukemia and non-small cell lung, colon, CNS, melanoma, and ovarian cancer cell lines with log GI50 values in the range of -4.14 to -5.72.

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