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Case Reports
. 1995 Oct;59(4):435-7.
doi: 10.1136/jnnp.59.4.435.

Chronic hypertrophic cranial pachymeningitis associated with HTLV-I infection

Y Kawano  1 , J Kira
Affiliations
Case Reports

Chronic hypertrophic cranial pachymeningitis associated with HTLV-I infection

Y Kawano et al. J Neurol Neurosurg Psychiatry. 1995 Oct.

Abstract

Two patients presenting with recurrent multiple cranial neuropathy showed diffuse thickening and gadolinium enhancement of the dura mater on brain MRI. Both had anti-HTLV-I antibodies in serum. A quantitative polymerase chain reaction study of the peripheral blood disclosed that the HTLV-I proviral DNA loads increased considerably in one case and moderately in the other. Both showed a spontaneous proliferation of peripheral blood lymphocytes as well as an increase in helper/inducer T cells. Neither had any other underlying infections or autoimmune diseases. Thus it is possible that hypertrophic pachymeningitis developed as a result of multiorgan involvement of HTLV-I infection in these patients.

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