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Review
. 1995 Jun;7(3):221-3.
doi: 10.1179/joc.1995.7.3.221.

Brodimoprim, a new bacterial dihydrofolate reductase inhibitor: a minireview

P Periti  1
Affiliations
Review

Brodimoprim, a new bacterial dihydrofolate reductase inhibitor: a minireview

P Periti. J Chemother. 1995 Jun.

Abstract

This brief review article synthesizes the principal literature regarding the clinical status of co-trimoxazole compared to monotherapy with one of the two diaminopyrimidines available commercially: trimethoprim or brodimoprim. Both these inhibitors of bacterial dihydrofolate reductase compare favorably to co-trimoxazole as antimicrobial chemotherapy. Brodimoprim is characterized by its advantageous pharmacokinetics in comparison to both co-trimoxazole and trimethoprim.

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