doi: 10.1038/377309a0.
A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome
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- PMID: 7566085
- DOI: 10.1038/377309a0
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A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome
Nature.
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Erratum in
- Nature 1995 Nov 23;378(6555):419
Abstract
Interaction of the conserved CCA terminus of tRNA with rRNA in the peptidyl transferase P site has been studied by in vitro genetics. A watson-Crick G-C pair between G2252 in a conserved hairpin loop of 23S rRNA and C74 at the acceptor end of tRNA is required for proper functional interaction of the CCA end of tRNA with the ribosomal P site. These findings establish a direct role for 23S rRNA in protein synthesis.
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