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. 1995 Sep 28;377(6547):309-14.
doi: 10.1038/377309a0.

A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome

R R Samaha  1 , R Green, H F Noller
Affiliations

A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome

R R Samaha et al. Nature. .

Erratum in

  • Nature 1995 Nov 23;378(6555):419

Abstract

Interaction of the conserved CCA terminus of tRNA with rRNA in the peptidyl transferase P site has been studied by in vitro genetics. A watson-Crick G-C pair between G2252 in a conserved hairpin loop of 23S rRNA and C74 at the acceptor end of tRNA is required for proper functional interaction of the CCA end of tRNA with the ribosomal P site. These findings establish a direct role for 23S rRNA in protein synthesis.

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