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. 1995 Sep 21;11(6):1207-10.

RET/PTC oncogene activation is an early event in thyroid carcinogenesis

G Viglietto  1 , G Chiappetta, F J Martinez-Tello, F H Fukunaga, G Tallini, D Rigopoulou, R Visconti, A Mastro, M Santoro, A Fusco
Affiliations
  • PMID: 7566982

RET/PTC oncogene activation is an early event in thyroid carcinogenesis

G Viglietto et al. Oncogene. .

Abstract

RET/PTC oncogene activation occurs in about 20% of human thyroid papillary carcinomas. However, it is not known yet whether it is an early or late event in the process of thyroid carcinogenesis. Here we demonstrate, by using a combined immunohistochemical and reverse transcriptase-polymerase chain reaction based approach, that RET/PTC activation is present in 11 out of 26 occult thyroid papillary carcinomas analysed. Therefore, we conclude that it represents an early event in the process of thyroid cell transformation.

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