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. 1995;81(6):475-80.
doi: 10.1007/BF00931789.

Intestinal amebiasis: cyclic suppression of the immune response

P K Ghosh  1 , C Castellanos-Barba, L Ortiz-Ortiz
Affiliations

Intestinal amebiasis: cyclic suppression of the immune response

P K Ghosh et al. Parasitol Res. 1995.

Abstract

The cellular immune response was evaluated in a C3H/HeJ mouse model of intestinal amebiasis at 5-60 days postinoculation with Entamoeba histolytica. At various intervals, spleen lymphocytes were obtained from infected and noninfected control mice and cultured with concanavalin A (Con A), pokeweed mitogen (PWM), or ameba antigen. E. histolytica infection induced a cyclic depression of DNA synthesis when spleen lymphocytes were stimulated with a T-cell mitogen (Con A), a T- and B-cell (PWM) mitogen, or an ameba antigen. A similar response was observed in the determinations of interleukin-2 in the supernatants of Con A-stimulated spleen cells from infected mice. When spleen cells from E. histolytica-infected mice were stimulated with phorbol myristate acetate plus ionomycin, results indicated a signal-transduction defect. These alterations, observed at the cellular level, might facilitate invasion of the host by the parasite.

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