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Comparative Study
. 1995 Sep 12;92(19):8999-9003.
doi: 10.1073/pnas.92.19.8999.

Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier

T Saga  1 , R D Neumann, T Heya, J Sato, S Kinuya, N Le, C H Paik, J N Weinstein
Affiliations
Comparative Study

Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier

T Saga et al. Proc Natl Acad Sci U S A. .

Abstract

Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part because of specific binding to the target antigen. Experiments presented here demonstrate an analogous phenomenon in micrometastases; poor antibody penetration, attributable to a "binding-site barrier" phenomenon, can be seen in guinea pig micrometastases as small as 300 microns in diameter. Increasing the dose of antibody can partially overcome this limitation, but at a cost in specificity.

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