doi: 10.1126/science.7569903.
Regulation of hippocampal transmitter release during development and long-term potentiation
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- PMID: 7569903
- DOI: 10.1126/science.7569903
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Regulation of hippocampal transmitter release during development and long-term potentiation
Science.
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Abstract
Developmental changes in rat hippocampal transmitter release and synaptic plasticity were investigated. Recordings from pairs of pyramidal neurons in slices showed that an action potential in a CA3 neuron released only a single quantum of transmitter onto a CA1 neuron. Failures of synaptic transmission reflected probabilistic transmitter release. The probability of release (Pr) was 0.9 in 4- to 8-day-old rats and decreased to less than 0.5 at 2 to 3 weeks. Long-term potentiation (LTP) in 2- to 3-week-old rats was associated with an increase in Pr from a single synaptic site. The high initial Pr in 4- to 8-day-old rats normally occludes the expression of LTP at this stage.
Comment in
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Long-term potentiation in the CA1 hippocampus.Science. 1996 Mar 15;271(5255):1604-6. doi: 10.1126/science.271.5255.1604. Science. 1996. PMID: 8599121 No abstract available.
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