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Clinical Trial
. 1995 Sep;173(3 Pt 1):881-4.
doi: 10.1016/0002-9378(95)90359-3.

Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial

T Vutyavanich  1 , S Wongtra-ngan, R Ruangsri
Affiliations
Clinical Trial

Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial

T Vutyavanich et al. Am J Obstet Gynecol. 1995 Sep.

Abstract

Objective: Our purpose was to determine the effectiveness of pyridoxine for nausea and vomiting of pregnancy.

Study design: During an 11-month period 342 women who first attended Chiang Mai University Hospital antenatal clinic at < or = 17 weeks' gestation were randomized to received either oral pyridoxine hydrochloride, 30 mg per day, or placebo in a double-blind fashion. Patients graded the severity of their nausea by a visual analog scale and recorded the number of vomiting episodes over the previous 24 hours before treatment and again during 5 consecutive days on treatment.

Results: There was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0.0008). There was also a greater reduction in the mean number of vomiting episodes, but the differences did not reach statistical significance (p = 0.0552).

Conclusion: Pyridoxine is effective in relieving the severity of nausea in early pregnancy.

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