Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Jun;39(6):1376-8.
doi: 10.1128/AAC.39.6.1376.

Drug interactions with zidovudine phosphorylation in vitro

P G Hoggard  1 , G J Veal, M J Wild, M G Barry, D J Back
Affiliations

Drug interactions with zidovudine phosphorylation in vitro

P G Hoggard et al. Antimicrob Agents Chemother. 1995 Jun.

Abstract

We have investigated the effect of a range of drugs (some commonly coadministered with zidovudine [ZDV] to human immunodeficiency virus-positive patients) on intracellular phosphorylation of ZDV by stimulated peripheral blood mononuclear cells, Molt 4 cells, and U937 cells in vitro. Of the drugs tested (azoles, antiviral agents, antibiotics, and anticancer agents), only doxorubicin and ribavirin caused inhibition of anabolite formation as measured by high-performance liquid chromatography. This in vitro approach may provide important leads to potential interactions at the phosphorylation level in patients with human immunodeficiency virus disease. It is reassuring that so many commonly administered drugs do not alter ZDV phosphorylation.

PubMed Disclaimer

References

    1. J Clin Pharmacol. 1974 Feb-Mar;14(2):112-7 - PubMed
    1. Antimicrob Agents Chemother. 1994 Oct;38(10):2398-403 - PubMed
    1. Antimicrob Agents Chemother. 1981 Sep;20(3):420-3 - PubMed
    1. Antimicrob Agents Chemother. 1982 Jan;21(1):151-8 - PubMed
    1. Am J Med. 1982 Jul 20;73(1A):165-71 - PubMed

Publication types

LinkOut - more resources