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Clinical Trial
. 1995 Nov;72(5):1267-9.
doi: 10.1038/bjc.1995.498.

Phase II trials of rhizoxin in advanced ovarian, colorectal and renal cancer

D J Kerr  1 , G J Rustin, S B Kaye, P Selby, N M Bleehen, P Harper, M H Brampton
Affiliations
Free PMC article
Clinical Trial

Phase II trials of rhizoxin in advanced ovarian, colorectal and renal cancer

D J Kerr et al. Br J Cancer. 1995 Nov.
Free PMC article

Abstract

Rhizoxin is a tubulin-binding anti-neoplastic agent which is active in a range of murine tumour models. The recommended schedule, of intravenous (i.v.) bolus administration at a dose of 2 mg m-2 every 3 weeks, has been assessed in three phase II trials of ovarian, renal and colorectal cancer. In general terms the drug was fairly well tolerated, but the response rate was disappointing: 0/18, colorectal cancer; 0/18, renal cancer; 1 partial response (PR)/17, ovarian cancer.

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