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. 1995;77(6):456-61.
doi: 10.1016/0300-9084(96)88160-0.

Poly(ADP-ribose) polymerase: structure-function relationship

M Masson  1 , V Rolli, F Dantzer, C Trucco, V Schreiber, S Fribourg, M Molinete, A Ruf, E A Miranda, C Niedergang, et al.
Affiliations

Poly(ADP-ribose) polymerase: structure-function relationship

M Masson et al. Biochimie. 1995.

Abstract

Dissection of the human poly(ADP-ribose) polymerase (PARP) molecule in terms of its structure-function relationship has proved to be an essential step towards understanding the biological role of poly(ADP-ribosylation) as a cellular response to DNA damage in eukaryotes. Current approaches aimed at elucidating the implication of this multifunctional enzyme in the maintenance of the genomic integrity will be presented.

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