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. 1978 Nov 1;146(3):465-73.
doi: 10.1016/s0378-4347(00)81205-0.

Determination of molsidomine in plasma by high-performance liquid column chromatography

D Dell, J Chamberlain

Determination of molsidomine in plasma by high-performance liquid column chromatography

D Dell et al. J Chromatogr. .

Abstract

A high-performance liquid chromatographic method is described for the analysis of the anti-anginal compound 5-ethoxycarbonyl-3-morpholinosydnonimine (Molsidomine) in human and dog plasma. The drug was extracted from plasma into chloroform and the analysis was carried out on a reversed-phase column, the column effluent being monitored by UV absorption at 312 nm. The method is sensitive (2 +/- 0.3 ng/ml) and specific. The method was applied to a study in which human volunteers received an aqueous solution of the drug and then, on a separate occasion, a tablet formulation. Peak plasma levels of 20--30 ng/ml (tablet) and 10--19 ng/ml (aqueous solution) were obtained following a 2-mg oral dose.

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