[The relationship between antipyrine kinetics, the seromucoid content and the xanthine oxidase activity in the plasma of rats with acute and chronic inflammation]

Abstract

The relationship between changes in seromucoid levels, xanthine oxidase activity in plasma, and drug metabolism in rats with turpentine-induced inflammation and adjuvant-induced arthritis was studied. For antipyrine, systemic clearance decreased, the volume distribution remained the same, and the half-life increased in turpentine- and adjuvant-treated rats. In both cases seromucoid level and xanthine oxidase activity in plasma increased. Treatment of rats with dexamehasone before turpentine-induced inflammation raised the level of seromucoid. However, dexamehasone treatment of rats with adjuvant disease significantly decreased the level of seromucoid. Moreover, dexamehasone administration did not significantly protect against the effects of inflammation on the hepatic microsomal drug-metabolizing enzyme system and activity of xanthine oxidase in plasma. Thus, pharmacokinetics of different drugs can significantly change in some types of inflammation in animals and humans, particularly by dexamehasone administration.