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. 1995 Nov;11(3):241-7.
doi: 10.1038/ng1195-241.

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

E Lander  1 , L Kruglyak
Affiliations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

E Lander et al. Nat Genet. 1995 Nov.

Abstract

Genetic studies are under way for many complex traits, spurred by the recent feasibility of whole genome scans. Clear guidelines for the interpretation of linkage results are needed to avoid a flood of false positive claims. At the same time, an overly cautious approach runs the risk of causing true hints of linkage to be missed. We address this problem by proposing specific standards designed to maintain rigor while also promoting communication.

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Comment in

  • Crimes against genetics.
    [No authors listed] [No authors listed] Nat Genet. 1995 Nov;11(3):223-4. doi: 10.1038/ng1195-223. Nat Genet. 1995. PMID: 7581436 No abstract available.
  • Thresholds and sample sizes.
    Kruglyak L. Kruglyak L. Nat Genet. 1996 Oct;14(2):132-3. doi: 10.1038/ng1096-132. Nat Genet. 1996. PMID: 8841180 No abstract available.

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