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. 1995 Nov;11(3):287-93.
doi: 10.1038/ng1195-287.

A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity

R E Straub  1 , C J MacLean, F A O'Neill, J Burke, B Murphy, F Duke, R Shinkwin, B T Webb, J Zhang, D Walsh, et al.
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A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity

R E Straub et al. Nat Genet. 1995 Nov.

Abstract

In 265 Irish pedigrees, with linkage analysis we find evidence for a vulnerability locus for schizophrenia in region 6p24-22. The greatest lod score, assuming locus heterogeneity, is 3.51 (P = 0.0002) with D6S296. Another test, the C test, also supported linkage, the strongest results being obtained with D6S296 (P = 0.00001), D6S274 (P = 0.004) and D6S285 (P = 0.006). Non-parametric analysis yielded suggestive, but substantially weaker, findings. This locus appears to influence the vulnerability to schizophrenia in roughly 15 to 30% of our pedigrees. Evidence for linkage was maximal using an intermediate phenotypic definition and declined when this definition was narrowed or was broadened to include other psychiatric disorders.

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Comment in

  • Schizophrenia susceptibility and chromosome 6p24-22.
    Mowry BJ, Nancarrow DJ, Lennon DP, Sandkuijl LA, Crowe RR, Silverman JM, Mohs RC, Siever LJ, Endicott J, Sharpe L, et al. Mowry BJ, et al. Nat Genet. 1995 Nov;11(3):233-4. doi: 10.1038/ng1195-233. Nat Genet. 1995. PMID: 7581441 No abstract available.
  • Schizophrenia susceptibility and chromosome 6p24-22.
    Gurling H, Kalsi G, Chen AC, Green M, Butler R, Read T, Murphy P, Curtis D, Sharma T, Petursson H, Brynjolfsson J, et al. Gurling H, et al. Nat Genet. 1995 Nov;11(3):234-5. doi: 10.1038/ng1195-234. Nat Genet. 1995. PMID: 7581442 No abstract available.
  • Schizophrenia susceptibility and chromosome 6p24-22.
    Antonarakis SE, Blouin JL, Pulver AE, Wolyniec P, Lasseter VK, Nestadt G, Kasch L, Babb R, Kazazian HH, Dombroski B, et al. Antonarakis SE, et al. Nat Genet. 1995 Nov;11(3):235-6. doi: 10.1038/ng1195-235. Nat Genet. 1995. PMID: 7581443 No abstract available.

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